GHB, or gamma- hydroxybutyrate, is a normal constituent of mammalian biochemistry.

It is found naturally in every cell in the human body. In the brain, the highest amounts occur in the hypothalamus and basal ganglia [Gallimberti, 1989]. GHB is found in even greater concentrations in the kidney, heart, skeletal muscles, and brown fat [Chin, 1992]. It is believed to be a neurotransmitter, although the jury is still out as to whether it exhibits all of the properties required for fulfillment of this function [Chin, 1992]. It is both a metabolite and precursor of the inhibitory neurotransmitter GABA (gamma-aminobutyric acid), to which it bears a close relationship of chemical structure. GHB, however, does not act on GABA receptor sites [Chin, 1992].

GHB was first synthesized about thirty years ago by H. Laborit, a French researcher interested in exploring the effects of GABA in the brain. Direct administration of GABA would not be effective for this purpose because it does not cross the blood- brain barrier. Laborits alternative was to administer GHB, which does cross the blood-brain barrier, and some of which, once inside the brain, metabolizes into GABA [Vickers, 1969].

Independently of its relationship to GABA, however, GHB turned out to be a drug with its own range of effects. It has since been widely used and researched, finding applications in obstetrics and general anesthesia and in the treatment of alcohol withdrawal syndrome, narcolepsy, insomnia, and other arenas.

During the 1980s, GHB was widely available over-the- counter in health-food stores, purchased largely by body-builders for its ability to aid in fat reduction and muscle-building. In the last few years it has been gaining popularity as a recreational drug offering a pleasant, alcohol-like, hangover-free high and potent prosexual effects.

We have extensive research papers on GHB, the facts about it, how it can be obtained and how it is used recreationally. We also have the complete synthesis for GHB.